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Coronavirus: Survivors’ antibodies are ‘most potent’ yet found

Scientists claim they have discovered the most potent antibodies yet in the blood of Covid-19 patients, raising hopes that people will develop immunity to the virus.

The antibodies were taken from the blood of several Covid-19 survivors and can neutralise the coronavirus, stopping it from entering cells.

These antibodies are cloned and scaled up in large quantities in the laboratory before being injected as a treatment. 

Experts discovered a cocktail of the extremely strong antibodies protected hamsters from Covid-19 when exposed to the SARS-CoV-2 virus. 

It’s only early findings, but the scientists say the antibodies -substances used by the immune system to destroy viruses – are ‘ready to be developed into treatments’. 

Administered in doses like a vaccine, scientists say antibodies could give humans the ability to avoid being struck down by the disease. 

Antibodies made in the laboratory to mimic natural antibodies have been used in the treatment of a huge range of conditions, including arthritis, Crohn’s and Ebola. 

Antibodies are proteins produced by the immune system in response to the presence of a foreign substance, like the coronavirus. 

The role of antibodies is to latch on to foreign substances like the coronavirus and mark it for other immune cells, such as T-cells, to kill. 

Neutralising antibodies are able to kill the virus themselves, rather than just tagging it for other immune cells to attack.

David Ho, scientific director of the Aaron Diamond Aids Research Centre and professor of medicine at Columbia University Vagelos College of Physicians and Surgeons, directed the study. 

He said: ‘We now have a collection of antibodies that’s more potent and diverse compared to other antibodies that have been found so far, and they are ready to be developed into treatments.’ 

Forty Covid-19 patients who were treated at Columbia University Irving Medical Center in New York City, but had since recovered were enrolled for the research.

Blood samples from all were first tested for neutralising activity against the virus. Scientists put their blood in a petri dish to see if antibodies attack or bind to the virus.

The team saw a wide range of neutralising antibodies, but focused on five patients whose plasma showed the highest levels of neutralising antibodies.

The five patients were all hospitalised for Covid-19, suggesting those with severe disease requiring mechanical ventilation produce the best neutralising antibodies.

Among them, 19 neutralising antibodies which ‘exhibited exquisite potency’ were discovered, according to the findings published in the journal Nature. 

Professor Ho said: ‘We think that the sicker patients saw more virus and for a longer period of time, which allowed their immune system to mount a more robust response.

‘This is similar to what we have learned from the HIV experience.’

The research team found a more diverse variety of antibodies than previous efforts, including new, unique antibodies that were not reported earlier.

The findings also revealed which sites on the viruses outer ‘spike’ are most vulnerable.

Professor Ho said: ‘Using a cocktail of different antibodies that are directed to different sites in spike will help prevent the virus becoming resistant to the treatment.’

The researchers took the neutralising antibodies and engineered them in the laboratory to create monoclonal antibodies (mAbs) – clones that work in the same way as the natural antibodies.

To assess if they worked, the researchers exposed hamsters to the coronavirus after an injection of the mAbs.

The hamster’s lung tissues were harvested to quantify the viral load four days later.

Hamsters given a higher dose of mAbs had considerably less viral particles than those given a low dose as a control group. 

The researchers said there was ‘complete elimination of infectious SARS-CoV-2 at a relatively modest antibody dose’.

Professor Ho is hopeful the findings will lead to treatment in people, which would first require clinical trials to ensure safety. 

It’s not clear how long this would take, but it may be quicker than a number of drugs and vaccines in development for Covid-19. 

The development and approval of antibodies for use as a treatment usually takes less time than conventional drugs. 

Scientists all over the world are looking at monoclonal antibody therapy for the new coronavirus but there are few currently in clinical trials. 

Last month, researchers at Scripps Research, in San Diego, also claimed to have discovered super-potent antibodies which protected animals from severe illness.  

Drug giant AstraZeneca also revealed it was working on an injection with cloned antibodies that could be ready next year.

Chief executive Pascal Soriot told The Sunday Telegraph the therapy being made is ‘a combination of two antibodies’ in an injected dose. 

The discovery of super potent antibodies also bodes well for vaccine development, too, scientists say.

If the immune system can generate such strong antibodies, vaccines that do the same ‘should provide robust protection against the virus,’ Professor Ho said.

However, questions remain over whether Covid-19 survivors develop any immunity once they recover from the disease.

Therefore, it will not be clear how long antibodies produced triggered by a vaccine would protect a person.  

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