Alzheimer’s disease warning: A new aggressive type of the disease has been discovered, and it hits people in their early 40s.
ALZHEIMER’S researchers have discovered a new form of the incurable disease, which strikes in the early 40s and advances rapidly, according to the researchers.
The alarming news comes after the discovery of an ultra-rare gene mutation linked to Alzheimer’s disease in its early stages. Alzheimer’s disease is the most common kind of dementia, with symptoms of memory loss appearing around the late 60s. However, a Swedish-based international team of researchers has discovered an aggressive variant of the disease that manifests much sooner.
The discovery was discovered after the researchers traced the mutation through numerous members of a single family, according to an article in Medical Xpress.
The research was motivated by a pair of 43-year-old and 40-year-old siblings at Uppsala University Hospital who were already showing signs of Alzheimer’s disease.
Because a close relative of the same age was exhibiting very similar symptoms, the researchers decided to look into a genetic reason for the family’s affliction.
It was eventually discovered that the siblings’ father had experienced the same symptoms two decades prior, around the age of 40.
The brothers and their cousin struggled to speak and execute simple maths as the sickness worsened.
The Uppsala APP deletion is the term given to this type of Alzheimer’s disease by the researchers, who described it in the journal Science.
“Here, we describe the Uppsala APP mutation, the first documented deletion producing autosomal dominant Alzheimer’s disease,” the study’s authors stated (AD).
“Affected persons are in their early forties when symptoms first appear and have a quickly progressive disease course.”
Dementia affects an estimated 850,000 people in the UK, with that number expected to climb to 1.6 million by 2040.
Alzheimer’s disease is responsible for 50 to 75 percent of all dementia cases.
According to the Alzheimer’s Society of the United Kingdom, 209,600 people will develop dementia this year, or one every three minutes.
Dementia affects about one in every six persons over the age of 80, and 42,000 people under the age of 65 have been diagnosed.
The Uppsala APP mutation has only been found in one family so far, making it a very unusual but nonetheless dangerous hazard.
The DNA alteration, according to researchers at Uppsala University in Sweden, accelerates the production of amyloid beta, a brain-damaging protein plaque.
When the plaques are placed. “Brinkwire News in Condensed Form.”