Press "Enter" to skip to content

Thousands of clinical trials to find drugs for cancer and heart disease have stopped due to Covid-19

Thousands of trials to find new treatments for diseases including cancer and heart disease have been halted because of the Covid-19 pandemic.

Seven in 10 NHS research projects have been affected by the coronavirus outbreak, an analysis by Southampton University found. One in 10 — a total of 1,500 including clinical trials of new medicines as well as lab research — have been stopped entirely because of the virus.

Dr Michael Head, study author, said all areas of health had been impacted and many had taken a backseat while research into Covid-19 steamed ahead.  

Charities working on cures and therapies for cancer and heart disease are likely to have been hard-hit by a fall in funding for research. But Dr Head warned that the smaller charities fuelling research for rare diseases that already have few treatments will find it hard to carry on at all.

It comes as a cancer charity today revealed that the anxiety surrounding cancer has been ‘higher than ever’ because of Covid-19, with patients worrying about spiralling waiting times and delayed trials. 

The figures shine a light on the catastrophic effect that Covid-19 has had on UK medical research.

And they come amid concerns about delays in care for other diseases, caused by coronavirus, which has led medics to warn survival rates could fall. 

In March, the National Institute for Health Research (NIHR) said new clinical trials were to be suspended to prioritise Covid-19 studies, such as for treatment and vaccines.

Trials in the recruitment stage were also halted, with NHS trusts and health boards making decisions on a case by case basis.  

Hospital trusts had to consider if trial participants could be protected from Covid-19 because many experimental drugs can compromise the immune system, making volunteers even more susceptible to the infection.   

The aim of pausing research also helped with the redeployment of clinical staff to frontline care to help treat the swathes of Covid-19 patients.

Clinical trials include caregivers and nurses who care for the patients involved, as well as the research scientists.

Laboratories have largely been requisitioned for mass coronavirus testing, and it’s not clear for how long they will be needed. 

Around 200 new trials are typically added to NIHR’s Clinical Research Network (CRN) portfolio each month — 2,400 a year. 

In 2018-19, the CRN supported over 6,100 studies and recruited over 870,000 participants.  

University of Southampton looked at the Edge database, which is used by NHS trusts to give information on research being conducted on NHS sites.

Early findings revealed that 70 per cent of research was impacted in some way as a result of Covid-19.

It includes clinical trials as well as epidemiology and laboratory studies, such as those looking at risk factors for diseases. 

Some 60 per cent of projects – a total of 9,000 – were paused. They may have stopped recruiting patients because the risk of Covid-19 infection in hospitals was too high.

Some 10 per cent – 1,500 – were shut down all together.

It is unclear currently the exact reasons why each was stopped, but possible reasons include the research being time sensitive or they did not have enough money to wait until after the outbreak, for example.  

Dr Head told MailOnline: ‘I guess looking back and reflecting, the numbers are not surprising. The pandemic has taken the world by surprise. 

‘We’ve shown globally and in the UK we are not prepared, and that will impact on research. 

‘Research is directed towards Covid-19, which is necessary. But obviously that will impact on other areas of health. In terms of preparedness for the future, we need to make sure non-Covid types of research are in planning.’

The research is ongoing and so it is unclear exactly what areas have been impacted the most. This will become clearer over the next few months.

Dr Head said: ‘It might be that cancer research was not affected but stroke and mental health was. It won’t just be large diseases, but areas of health with few cases.

‘There will be research impacted that what will be rare or orphan diseases, where there isn’t much treatment available. 

‘Aspects of that might include motor neurone disease or haemophilia. If they are impacted it might hard for those charities to carry on.’

He added that it will be important to discover what knowledge would have been found had Covid-19 not halted medical research.

These ‘knowledge gaps’ will be important for moving forward in the treatment of patients, he said.

Dr Head told The Observer: ‘This pandemic has knocked everything off track. Research gives us the knowledge we need to tackle illnesses in new ways, and if that doesn’t happen all areas of health will suffer.’ 

A stark example of the harm caused to medical research by the pandemic is to cancer research, as large charities have revealed the devastation in stark numbers.  

‘We had planned to spend £400m on research this year. That figure will have to be cut to £250m,’ Aoife Regan of Cancer Research UK told the Observer.

‘That is £150m of research on treatments with the potential to save or lengthen lives that will not now take place.’

If cuts continue to persist for four or five more years, it would mean hundreds of millions of pounds will be stripped from cancer research in the UK in coming years which will ‘send ripples beyond that’. 

The impact of Covid-19 on cancer patients has been at the forefront of discussions during the pandemic. 

Dame Laura Lee, the chief executive of cancer charity Maggie’s, today said the past few months have been a difficult time for cancer patients.

Speaking on the BBC Radio 4 Today programme, she said: ‘It’s been hugely difficult. Cancer is not just a physical illness but it’s the psychological effects that has not just on the person but also the family.

‘With auto treatments and on many occasions treatment being ceased, people with cancer dying during this period, or finding that their disease has progressed, it’s been a heightened time of distress and anxiety.

‘Cancer always brings anxiety, a sense of aloneness, but during this Covid time, it’s been higher than ever. 

‘People are coming into our centres with that knowledge and information of what they’ve heard and worrying, “what does that mean for me?”

‘Our centre staff have never said they’ve ever dealt with such level of distress, feelings of anger, about the situation they find themselves in and actually, to a certain extent, feelings of abandonment with the NHS as well.’ 

Shannon Amoils, of the British Heart Foundation, said its research had ‘ground to a halt’ during the pandemic. 

A study at Edinburgh University was set to determine if specific drugs could prevent stroke patients from going on to develop vascular dementia. 

Another study at Newcastle University aimed to find out if non-invasive treatments could be used instead of surgical interventions for elderly men and women who had suffered heart attacks. 

Brian Dickie, of the Motor Neurone Disease Association, warned time was critical for the research of motor neuron diseases – which affect about 5,000 people in the UK.

He said: ‘Around 50 per cent of people with motor neurone disease will die within 18 months of their first diagnosis.’

Work to determine whether a drug called Tudca could stop the disease progressing is among the suspended trials.

Dr Dickie said: ‘These individuals are rapidly running out of time, so suspending projects like these is utterly heartbreaking.’    

The British Lung Foundation said in May it had had to pause a phase two clinical trial for new drugs to treat malignant pleural mesothelioma.

The condition has no cure and just five per cent of men and 10 per cent of women survive for more than five years.

Dr Samantha Walker, the director of research and innovation at Asthma UK and the British Lung Foundation, told The Telegraph: ‘This is not good news for a cancer where survival rates are dismal and there is no cure.

‘We completely understand the need to focus on Covid-19 right now, but the impact will be colossal, with huge repercussions on the research community and patients who, heartbreakingly, don’t have time to spare. This will mean delays in the trial going ahead and any potential new treatments reaching those who need them.’

Michael Lauer, deputy director for extramural research at the US National Institutes of Health, said the effect of Covid-19 on medical research goes beyond just trials.

In a article for The Lancet last week, he said: ‘There have also been tremendous disruptive effects on all biomedical research that is not directly related to Covid.

‘Laboratories are closed. Communications have been shut down, conferences have been cancelled, supply chains for equipment have been lost, resources have been lost. There have been widespread financial losses within academic medical centres that have had spillover effects on their research operations.’ 

Be First to Comment

Leave a Reply

Your email address will not be published. Required fields are marked *