What exactly is L452R? Here’s what we know about the Covid-19 strain, which has been linked to many California outbreaks.


What exactly is L452R? Here’s what we know about the Covid-19 strain, which has been linked to many California outbreaks.

It’s too early to tell if this Covid-19 version will spread faster than others, according to public health officials.

In California, scientists have discovered a new coronavirus variety that has been connected to many outbreaks in Santa Clara County. This strain, known as ‘L452R,’ is not the same as the B.1.1.7 variety that was recently detected in the United Kingdom.

The 452R variant has previously been reported in other countries and states, including California, and is now progressively being found in several counties throughout the state, according to public health officials. Many infections have been reported at the Kaiser Permanente medical center in San Jose as a result of one of the outbreaks, according to authorities.

“An L452R variant of Covid-19 is increasingly being detected by viral genomic sequencing in numerous counties across the state,” according to a statement released by the California Department of Public Health (CDPH) in collaboration with Santa Clara County and UCSF.

In mid-November 2020, scientists at the University of California San Francisco (UCSF) analyzed coronavirus genomes collected from around the state and discovered that the variation was present in 3.8 percent of the samples. It had risen to 25.2 percent by January 2021.

Hello everyone, we and other labs in California discovered a L452R spike mutation SARS-CoV-2 variant 3.8 percent -> 25.2 percent cases in Santa Clara County in mid-November/early January, associating with many high attack rate outbreaks. @SCCgov @UCSF @CAPublicHealth @CDCgov Epi/lab studies are pending. https://t.co/F0flvNqWaX — Charles Chiu (@cychiu98) on Twitter: pic.twitter.com/opJs9fllm9 18th of January, 2021 There are three mutations. The spike protein, which the virus uses to connect to and enter cells, has three alterations in this 452R version, including L452R. The spike protein is the target of the coronavirus vaccines now available in the United States from Pfizer and Moderna.

“Variants of viruses like SARS-CoV-2 (the virus that causes Covid-19) are frequent, and we’re working with our federal, state, and academic partners to better understand this variant and how it can affect Californians.” It’s too early to say if this strain will spread faster than others, but it clearly underlines the need for all Californians to wear masks and limit their contact with people beyond their immediate families to help restrict the virus’s spread,” says Dr. Erica Pan, CDPH’s state epidemiology.

What does this imply?

It is yet unknown whether the new version is more contagious. To understand more about the variant and restrict its spread, the state is collaborating with the Centers for Disease Control and Prevention (CDC), local public health departments, and laboratory sequencing partners. They want to know if the variation transmits more easily from person to person and if so, how quickly. Brinkwire News in a Nutshell


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