Scientists have discovered “more effective methods for prevention and treatment” of gum disease.


Scientists have discovered “more effective methods for prevention and treatment” of gum disease.

The inflammation in the gums that leads to tooth loss and bone damage has been linked to a blood clotting protein.

Disabling it could be used as a preventative measure.

Gum disease, which affects half a billion people worldwide, has been linked to the blood clotting protein fibrin.

The immune system reacts to the protein buildup in the gums, causing the gums and underlying bones to deteriorate.

The study, which was published in Science, speculates on a future treatment that would target the build-up of fibrin before it causes a harmful response.

The findings may also shed light on other inflammatory diseases like arthritis and multiple sclerosis, according to the researchers.

Excess fibrin buildup has been linked to a number of genetic conditions.

Inflammatory diseases of the mouth and other body parts have been linked to plasminogen deficiency, an enzyme that breaks down fibrin after it has done its job or blocked a wound.

Researchers looked at over 1,000 people’s genetic profiles and discovered that variations in the plasminogen gene were linked to more severe gum disease.

They also found that when this gene was turned off in mice, the mice developed severe gum disease as a result of immune cells attacking the gums.

Lakmali Silva, the study’s lead author, is optimistic that the findings will aid in the development of a treatment.

Preventing harmful interactions between fibrin and immune cells known as neutrophils could limit the damage caused by gum disease.

“Our findings support the notion that focusing on the fibrin-neutrophil interaction could be a promising treatment avenue to investigate in both rare and common forms of periodontitis,” Silva said.

Other inflammatory conditions caused by an overactive immune response, such as arthritis and multiple sclerosis, may benefit from this research.

The National Institute of Dental and Craniofacial Research (NIDCR), which is part of the National Institutes of Health, conducted the study.

“Severe periodontal disease can lead to tooth loss and remains a barrier to productivity and quality of life for far too many Americans, especially those who lack adequate access to dental care,” said NIDCR director Rena D’Souza, Ph.D.

“This study brings us closer to more effective prevention and treatment methods by providing the most comprehensive picture yet of the underlying mechanisms of periodontal disease.”

This type of basic research is noted by the National Institutes of Health.

“News from the Brinkwire.”


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