The thesis by Dr. Zubieta is now published in the open access journal, Reviews of Recent Clinical Trials.
The current COVID-19 pandemic has claimed more than 1 million lives, and has caused significant progressive pulmonary disability.
The desire to understand this disease has brought together research that document how it is spread and its symptoms.
Physicians from Bolivia who live and work at more than 3,600 meters above sea level have a unique viewpoint on altitude sickness due to the high relative altitude.
At altitude, hypoxemia has been a constant fact at La Paz’s Institute of Altitude Illness and Pathology (IPPA) for over 50 years due to altitude sickness. Surprisingly, unlike altitude sickness, according to Professor.
An enticing new idea, Dr. Gustavo Zubieta-Calleja, COVID-19 is entitled “pneumolysis” (pneumo=lung, lysis=destruction).
Originally, all physicians worldwide believed that lung involvement in COVID-19 may be the same as in older strains of SARS-CoV. However, as death rates in the intensive care unit (ICU) grew, it became apparent that this pattern was entirely new.
The SARS-CoV-2 virus reaches the body through inhalation and passes through the lungs to the alveoli where the alveolar cells and capillaries are found.
The lung cells cause oxygen to diffuse into the bloodstream, and then it is taken up by red blood cells and distributed across the body.
They allow the passage of carbon dioxide which helps to rid the body of its waste products.
Ebola virus 2 joins human alveolar macrophages and starts its own replication of its own RNA. The viral replication in the pneumocytes ultimately contributes to the release of replicated SARS-CoV-2 RNA and infection of other nearby pneumocytes.
The post, authored by Prof.
Based on disease characteristics, many diseases can result from SARS-CoV-2 infecting capillaries.
The coronavirus causing the gas exchange surface of the lungs to deteriorate.
Subsequently, this contributes to inflammation of the alveoli and a superimposed improvement in lung function (HAPE).
When the concentration of carbon dioxide is raised in a patient, they cannot take in enough oxygen, even though they were rapidly transported to the summit of Mt.
Everest without enough time to adapt. While HAPE is non-lethal, it is reversible since the mechanism is different and none of the alveoli are killed.
The serious hypoxemia that occurs in COVID-19 patients prompts physicians to use mechanical ventilators to provide sufficient oxygenation. In cases of milder cases, applying high pressures to weakened lungs can lead to some of the worst outcomes.
When compared to passive ventilation noninvasive ventilation leads to better outcomes.
Patients who survive acute pneumocystosis with critically low oxygen levels in COVID-19 will have permanent lung scarring.
Damaged tissue can no longer conduct gas exchange in the lungs. Compensation can also be accomplished by increasing the number of red blood cells (hemoglobin oxygen transporters).
A poly-erythrocythemia of altitude is a compensatory mechanism observed in altitude dwellers suffering from chronic lung disease or other oxygen transport disorders.
COVID-19 states that hemoglobin may be deficient at altitude.
The authors suggest that an improvement in oxygen transport can be achieved by administering erythropoietin.
This hormone fills the body with red blood cells to increase the oxygen supply and protect the brain from the adverse effects of hypoxia.
Proper oxygen administration is vital because it avoids the production of HAPE and cardiopulmonary overload.
The use of anti-inflammatory medications, most commonly aspirin, is also recommended because of its analgesic effects, anti-inflammatory effects, antipyretic effects, and antiplatelet effects.
The use of antibiotics, oral rehydration, and other anti-coagulants when caused by a medical condition should be considered in each situation.
To prevent the use of W-type protective suits, Dr. Zubieta-Calleja recommends the use of Earth-type suits.