Liver disease: A commonly used medicine may increase the chance of this severe condition.
The prevalence of liver disease is on the rise. Liver disease-related mortality have climbed 400% since 1970. A common medicine that almost everyone has used at some point in their lives may be increasing your risk.
In the United Kingdom, about 40 individuals die every day from liver illness. Drinking heavily or being extremely overweight can cause liver cell damage and scarring. Cirrhosis is a stage of extensive scarring within the liver that develops over time. Paracetamol poisoning is a lesser-known risk factor for the condition.
When taken as indicated by the product instructions, paracetamol is an effective treatment for mild to moderate pain and fever in adults and children.
Within a 24-hour period, the maximum dose must never be exceeded.
Overdosing on paracetamol is one of the most common causes of abrupt liver failure.
Scientists have known for decades that excessive doses of paracetamol are toxic to the liver, but the mechanism of poisoning has evaded them until now.
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“Paracetamol is the world’s favored pain remedy,” said Dr Leonard Nelson of Edinburgh University. It’s inexpensive, and at therapeutic doses, it’s regarded safe and effective.
“However, medication-induced liver injury remains a significant clinical issue and a difficulty for therapeutic development.
“Our findings highlight the importance of caution while using paracetamol and may aid in determining how harm caused by its misuse might be avoided.”
Paracetamol and its effects on the liver were studied in a study published in Science Direct.
The research discovered that the medication can impair the liver by disrupting critical structural connections between nearby cells.
The liver tissue is injured when these cell wall connections, known as tight junctions, are disturbed, resulting in the cells’ inability to function effectively.
This damage occurs in liver diseases such as hepatitis, cirrhosis, and cancer, although it has never been associated to paracetamol toxicity.
According to the British Liver Trust, serious paracetamol overdoses are twice as common in Britain as they are in the rest of Europe.
“Paracetamol-linked liver failures, serious enough to necessitate a transplant, are eight times more common in the UK than in Holland, twice as common in France, and 66 times more common in Italy,” the website said.
“Last year, the European Medicines Agency commissioned a study of seven countries.”Brinkwire Summary News”.