Penile Intraepithelial Neoplasia Symptoms and Causes


Penile intraepithelial neoplasia (PIN or PeIN) is a treatable rare condition of precancerous lesion that affects the epidermal layer of the penis. Around 45-50% of penile malignancies are caused due to viral infection by Human Papillomavirus (HPV), of which HPV16 and HPV18 are major tumor causing agents. Non-HPV factors such as chronic inflammatory disease and lichen sclerosus can also cause penile cancers.

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The factors causing PeIN lead to symptomatic and asymptomatic conditions such as inflammatory and papulosquamous lesions, infectious lesions, and neoplastic lesions.

Inflammatory and papulosquamous lesions

Infectious lesions

There are some symptoms associated with infectious lesions such as genital herpes, and HPV lesions of the PeIN.

Neoplastic lesions


The abnormal cell growth on the epidermal layer of the penis is caused by the following factors such as HPV infection, chronic skin disease, exposure to ultraviolet rays, and formation of smegma.

HPV infection: HPV plays a major role in causing penile cancer by interacting with tumor suppressor genes such as Rb (Retinoblastoma) genes, tumor protein p53, and oncogenes. It has been found that the DNA of HPV is present in about 70 to 100% of intraepithelial neoplasia of the penis. Generally, people who undergo multiple sexual contacts have a greater risk of HPV infection that results in the development of penile lesions.

Chronic skin disease: The chronic skin disease that causes intraepithelial neoplasia includes lichen sclerosus, and lichen planus. In lichen sclerosus, the region of genetalia and the anus become weak and cause irritation, excoriation, and fissuring which leads to premalignant condition of penis. Lichen planus is an inflammatory condition that develops itchy and flat-topped bumps resulting in PeIN.

Exposure to ultraviolet rays: The exposure to ultraviolet rays comprising psoralen and ultraviolet on a surface of the skin can lead to DNA damage causing abnormal cell growth in the regions of glans and shaft of the penis.

Smegma: Smegma is a white-colored substance accumulated below the glans which has an elevated risk of causing penile tumors. This substance is not carcinogenic but enhances the risk of penile lesion by causing inflammation and pain in the penis.

Balanitis: Balanitis is a common condition that occurs in uncircumcised males, causing PeIN. This condition occurs due to some factors such as infection of the skin surface, poor hygiene, usage of rough soaps, and uncontrolled diabetes.

Human immunodeficiency virus (HIV): HIV is a subgroup of retrovirus that causes HIV infection, resulting in the damage of the immune system of the body. Males testing HIV positive have an eight times greater risk of premalignant lesions than males testing HIV negative.

Phimosis: Phimosis is a medical condition that is considered as a significant cause for penile cancer. It is an inability to redevelop the prepuce enveloping the glans of the penis.

Paraphimosis: Paraphimosis is also found in uncircumcised males in which the foreskin is struck behind the glans and cannot be further pulled to the tip of penis. This condition is a risk factor for the growth of PeIN.  

Smoking and tobacco chewing: Cigarette smoking and tobacco chewing are also considered as the high-risk factors of causing penile malignancy depending on the number of cigarettes and amount of tobacco utilized by an individual.

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